Endocrine Abstracts

A complex interaction between environmental and genetic/epigenetic factors is driving the escalating obesity and diabetes epidemics together with a multitude of associated comorbidities. In the past decades the role of gastrointestinal signals in energy homeostasis and glucose control has made tangible progress mainly due to the findings derived from bariatric/metabolic surgery. In particular, incretin-based approaches in relation with glucagon-like peptide 1 and amylin have f...

Obesity represents an important risk factor for type 2 diabetes mellitus (T2DM) development. The outcomes of both bariatric and metabolic surgery have provided new insights into the mechanisms responsible for body weight control and glucose homeostasis. However, at the same time the marked effects of metabolic surgery on T2DM highlights the limitations of our current knowledge underscoring the need to continue addressing relevant questions as regards the underlying mechanisms ...

Objectives: Metabolic dysfunction–associated fatty liver disease (MAFLD) is a new nomenclature for fatty liver disease (FLD). The clinical impact of the change in nomenclature on the ability to identify individuals at risk for cardiovascular disease (CVD) has not yet been elucidated. The aim of this study is to describe the cardiovascular risk and subclinical CVD of the different MAFLD subtypes.Methods: Retrospective analysis of patients who attende...

Aim: Epicardial adipose tissue (EAT) has important physiologic functions, nonetheless, excessive EAT leads to a proinflammatory state with adverse effects on the myocardium. EAT has also been associated with adverse outcomes in chronic kidney disease (CKD) patients. We think that visceral adipose tissue (VAT) and organ-specific ectopic fat plays an important role in cardiorenal dysfunction. The aim of our study is to analyse the relationship between EAT and the risk of develop...

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...

Obstructive sleep apnoea (OSA) is very common in severe obese patients and has been related to insulin resistance (IR) and hyperleptinemia, and these findings may have effects on food behavior and obesity complications. In order to explore this relationship and the role of sex we have studied 531 patients with morbid obesity (BMI 42.8+6.5 kg/m2). A full polysomnographic study and glucose, insulin and leptin measurements as well as air displacement plethysmography we...

Morbid obesity (MO) is often complicated by obstructive sleep apnoea (OSA), which in some cases is evaluated by pulsioximetry. This cross-sectional study was designed to investigate the prevalence of discordance between desaturation index (DI) and apnoea–hypopnoea index (AHI) and its effects on insulin resistance and secretion in MO patients candidate to bariatric surgery (n=496) in whom a full polysomnographic study was carried out. We identified 163 (33%) out o...

Aim: Non-alcoholic fatty liver disease (NAFLD) and type 2 Diabetes (T2D) are common conditions that frequently co-exist. Studies have shown an increase likelihood of micro and macrovascular complications in this population, as well, as an increased risk of developing more severe forms of liver disease. The aim of this study was to identify diabetic complications in patients with both diseases and search for an association with liver stiffness assessed by Liver Elastography (LE...

Objectives and methods: The mechanism that explains the different weight response to various treatments in obese type 2 diabetes (DM2) patients, compared to those without diabetes, is still unknown. In order to establish the weight response to Roux-en-Y Gastric Bypass (RYGB), 268 patients with morbid obesity (IMC 45.4±0.4 kg/m2) were classified by OGTT as having normal glucose tolerance (Grupo A. n=107), prediabetes (Grupo B. n=96) an...

Patients with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease, particularly patients with liver fibrosis. Studies have shown a relationship between epicardial fat/coronary calcium and myocardial ischemia.Aim: Quantify epicardial fat and coronary calcium assessed by computed tomography (CT) in patients with NAFLD. Additionally, determine whether patients with hepatic fibrosis quantitatively assessed by liver el...